Abstract
A toxin in chromatographically pure form has been isolated from natural blooms of the blue-green alga Aphanizomenon flos-aquae. The toxin is a strongly basic substance, which gives a positive ninhydrin reaction and appears to be a guanidine derivative. A dose of 2·7 μg injected intraperitoneally into 20 g mice caused death in 4·9 min. The purified toxin reversibly blocks action potentials and tension development in amphibian nerve-muscle preparations without alteration of the resting potential. The toxin differs from saxitoxin in some of its chemical and physical properties, and some of its effects on neuromuscular systems.
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