Abstract
As modern technologies advance, new methods of drug delivery systems are constantly being developed. Pulsatile drug delivery system is becoming increasingly popular because it can deliver the drug at the correct location, time, and dosage, improving patient adherence. These technologies are designed to align with the body's inherent circadian rhythm. Pulsatile drug release is mainly preferred when continuous drug release is not needed. Understanding the circadian clock's design, illness rhythm pathophysiology, and chrono pharmacology’s medication knowledge helps create and utilize chronotherapeutic dosage forms for effective disease treatment, reducing side effects, improving targeted drug delivery, and maintaining consistent dosing. Proper design of pulsatile drug delivery enhances patient adherence, targets drug distribution, and decreases side effects. Like many other medical conditions, the outlook for chronotherapy using pulsatile drug delivery seems very optimistic. Pulsatile drug delivery systems can utilize either one or multiple mechanisms to administer medication at a specific time and location. Formulation of pulsatile flow is achieved by incorporating different polymers, with the thickness of the coating layer dictating the speed of release of the active medicinal ingredient.
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