Psychotropic Agents Poisoning: Analysis of Cases Reported to Shahid Beheshti Drug and Poison Information Center

Abstract

Background: Antidepressants, antipsychotics and benzodiazepines overdose events are the most reported poisoning each year from Shahid Beheshti Drug and Poison Information Center (DPIC) (a branch of Iran Drug and Poison Information Center in Tehran), which clearly shows the necessity of providing prevention program and instruction plan in taking psychotropic agents.Methods: This survey was a descriptive retrospective study by reviewing 390 reported phone calls from Shahid Beheshti Drug and Poison Information Center (DPIC), in Tehran, through 2010 to 2012.Results: 390 reported cases of psychotropic agents including overdoses, medical errors such as extra dose, accidental exposure of medications, especially in children, cases of suicide, and intentional use (were) recorded. The main causes of poisoning calls to the DPIC, were included intentional and suicidal actions (40%), accidental events (27%), drug abuse (26%) and, medical errors (7%), respectively. Up to 50% of calls were about benzodiazepines (BZD) poisoning and the most adverse effects were Central Nervous System (CNS) effects followed by gastrointestinal side effects.Conclusion: According to the results, in order to achieve the proper effect of psychotropic agents and preventing related poisoning, providing pharmaceutical services and awareness of patients are necessary. It should be about the therapeutic effects and side effects of their medications by pharmacists and poison centers and limiting the accessibility of patients to large amounts of these medications by regulatory organizations.