Abstract
Dear Sir The recent published article by Dr. Pourmand and his colleagues under the title of A survey of poison control centers worldwide was read eagerly [1]. I have had the opportunity to work for Iran National Drug and Poison Information Center (NDPIC) and also Central Staff of NDPIC for several years. I would like to state my appreciation because of consideration of Iran poison centers and also I want to comment on the Iran section of that article. The first Iran Drug and Poison Information Center (DPIC) was founded in February of 1997 in the Food and Drug Deputy of Iran Ministry of Health and Medical Education by a group of experts and their first report of a such new activity was published by Nikfar and colleagues in the year 2000 [2]. The role of the center was to provide the best responses to questions and also consultations to healthcare professionals and public [2]. More than the enquiry service, all of the adverse reactions to medications were reported to the National Adverse Drug Reaction (ADR) center, and in order to increase the culture of rational use of drugs, the Iran DPIC participated in pharmacy and therapeutic committees; gave workshops and seminars; and produced information newsletters, pamphlets and articles [2]. At the moment, Iranian DPIC has a close collaboration with the National ADR Center and the Iranian Rational Use of Drugs (RUD) center, medical universities, and hospitals. The Iranian DPIC developed gradually and changed its name to National Drug and Poison Information Center (NDPIC). Alongside developing of NDPIC, the other DPICs were founded in Iranian medical universities. These DPICs are mainly supported by local medical universities as well as Iran Ministry of Health and Medical Education, and currently the Food and Drug Organization. All of these centers are under the
Highlights
Obesity has reached epidemic proportions and is still escalating at an alarming rate worldwide
Obesity is associated with chronic activation of low-grade inflammation [3], which is implicated in the pathogenesis of obesity-associated diseases including insulin resistance, type-2 diabetes (T2D) [4, 5] and cardiovascular disease [6, 7]
A numerous of studies has been shown that shortchain fatty acids (SCFAs) inhibit inflammation with focus on butyrate and to a lesser extent on acetate and Propionic Acid (PA), [16]
Summary
Obesity has reached epidemic proportions and is still escalating at an alarming rate worldwide. In Palestine the prevalence of obesity has been shown to be approximately 4. The etiology of obesity and low-grade inflammation is complex and involves intrinsic and extrinsic factors. The colonization of germ-free mice with microbiota derived from obese mice results in significantly greater adiposity than colonization with microbiota from lean mice [12]. Prebiotic diets such as fructans [13] are associated with general better health, including the decrease in body weight, fat mass and the severity of T2D [14,15,16]. The factors that influence the composition and metabolism of intestinal
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