Abstract
Publisher Summary Pseudomonas aeruginosa ( P. aeruginosa ) can be isolated from soil and water. It is an opportunistic pathogen of humans, other animals, and plants. One of the reasons that P. aeruginosa is a successful opportunistic pathogen is that it produces a battery of secreted virulence factors. These virulence factors include exoproteases, siderophores, exotoxins, and lipases. Many of these virulence factors are regulated by quorum sensing. Genetic studies have revealed two quorum-sensing systems in P. aeruginosa : the LasR-I and RhlR-I quorum sensing systems. Both these systems have linked R and I genes. A DNA sequence with dyad symmetry called a lux -box-like sequence can easily be identified in the promoter regions of many quorum-sensing controlled (qsc) genes. By analogy to other acyl-HSL quorum sensing systems it is deduced that the lux -box like sequences function as binding sites for LasR and RhlR. It is not yet clear how RhlR and LasR discriminate between their respective binding sites. Moreover, many genes show partial activation with either LasR or RhlR and the appropriate acyl-HSL.
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