Abstract
Pseudomonas- A potential Source for Drug Lead Discovery
Highlights
Since the very existence of human civilization natural sources have been considered as the basis for the treatment of several diseases
Discovery of new antibiotics such as penicillin from microorganisms has led to the expansion of pharmaceutical research based on microbial sources [3]
Bacteria with a small group of taxa have been recognized as potential source for the development of new drugs
Summary
Curr Trends Biomedical Eng & Biosci Copyright © All rights are reserved by Sajeli Begum Ahil. Microorganisms have always been considered as important resource in drug discovery. As there is always a need for medicines with higher efficacy and lesser side effects, pharmaceutical research based on natural sources still continues by playing a vital role in discovery and development of drugs. Bacteria have been identified as a potential spring for identifying new chemical entities. Pseudomonas is a diverse genus of Gammaproteobacteria which exhibits remarkable genomic diversity and is well recognized for the production of a variety of secondary metabolites. Pseudomonads have been shown to produce siderophores, pyoverdins, lipopeptides, numerous nonribosomally derived peptides, polyketides and small molecular weight antibiotics or phytotoxins which demonstrate remarkable biological activities. The pharmacological activities exhibited by metabolites of different Pseudomonas species are elaborated in this review to explore the scope of probing pseudomonas species for drug lead molecules
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