English

Abstract

The present study deals to evaluate comparatively the anti-diarrheal activity of an aqueous extract of root, stem and leaves of Murraya Koenigii in castor oil induced diarrhea in the Wistar albino rats. Wistar albino rats (About 180-200 gm) (Either sex) were taken. The animals were divided in to five groups with six rats in each group. Significant anti-diarrheal activity was observed in root, stem as well as leaves of Murraya Koenigii. In this experiment, the extracts treated rats showed significant reduction in the diarrheal fecal materials formation while the normal vehicle control or untreated group showed more frequently passage of watery diarrhea fecal materials with mucous secretions. The loperamide group showed significant (p<0.001) reduction in both number 0.66 (Mean), 0.82 (SD),*** p<0.001) and weight (1.14(Mean), 0.49 (SD),** p<0.01) of the faecal materials after 4 hr with respect to control group and its % of protection was 90.47% . All the three (root, stem and leaf of Murrya koenigii) extract successfully and significantly (*p<0.05. **p<0.01 and *p<0.05 respectively) reduced the number of diarrhea faeces formation but the aqueous stem extract of Murrya koenigii shown better % of protection(66.66%) as compared to other extracts (root and leaf).The stem shows maximum reduction in both number (1.33(Mean), 1.21 (SD),** p<0.01) and weight (1.42(Mean), 0.15 (SD),* p<0.05) of the faecal materials in comparison to the root and leaves of Murraya Koenigii respectively. The percentage protection of the stem was found to be 66.66 %.On the basis of these findings; it can be assumed that Murraya koenigii could be a potential source for novel lead discovery of newer anti-diarrheal herbal drugs.