Abstract
Mechanical trauma to the spinal cord leads to neural and molecular pathophysiological responses. Biomarkers are emerging as a promising unbiased tool that can assess the pathophysiological processes following spinal cord injury (SCI). In this concise review, we provide details of role and expression of structural, including Neurofilament Proteins (NF), Glial Fibrillary Acidic Protein (GFAP), Cleaved Tau (C-Tau), S100-β, Neuron Specific Enolase (NSE), Myelin Basic Protein (MBP), and inflammatory, including Transforming Growth Factor Beta (TGF-β), Tumor Necrosis Factor (TNF), Interleukins (ILs), Soluble CD95 Ligand (sCD95L) biomarkers in reported human and animal SCI studies.
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