Provocative Tests, Functional Exams and Daily Curve of Intraocular Pressure in Glaucoma Suspects

Abstract

Objective: To assess sensibility and specificity, positive and negative predictive values and probability of false-positive and false-negative of the water-drinking test, ibopamine test, frequency doubling perimetry, short-wave automated perimetry and daily curve of intraocular pressure in glaucoma suspects. Methods: Glaucoma suspect eyes and normal control eyes from age-matched individuals, both with normal standard automated perimetry, were submitted to water-drinking test, ibopamine test, frequency doubling perimetry, short-wave automated perimetry and daily curve of intraocular pressure. Results: We included 45 Glaucoma suspect and 30 normal control eyes. Sensibility and specificity were respectively 75.6% and 100% for daily curve of intraocular pressure; 35.6% and 80% for ibopamine test; 22.2% and 96.7% for short-wave automated perimetry; 15.6% and 96.7% for water-drinking test; 8.9% and 100% for frequency doubling perimetry. Positive and negative predictive values of the same workups were: 100% and 99.5%; 3.5% and 98.4%; 12% and 98.4%; 8.7% and 98.2%; 100% and 98.2%. False-positive and false-negative probabilities were: 0% and 0.5%; 96.5% and 1.6%; 91.3% and 0%; 88.0% and 1.6%; 0% and 1.9%. Conclusions: The daily curve of intraocular pressure presented the highest sensibility with the highest positive predictive value. frequency doubling perimetry presented a very low probability of false-negative. ibopamine test, water-drinking test and short-wave automated perimetry presented a very high probability of false-positive.