Abstract
Periodontitis is attributed to the dental biofilm formation caused by various microbial changes that occurs in the biofilm. Red complex organisms are a group of organisms linked with periodontal diseases. Therefore, it is of interest to identify potential targets from the red complex organisms to bind with the herbal compound silymarin. We report a list of potential proteins having optimal drug like binding features with the herbal agent silymarin for further consideration. We used the STITCH v.5 pipeline using VICMPred and VirulentPred tools to identify such targets as potential virulent factors in the red complex organisms. We considered the strains of Porphyromonas gingivalis ATCC 33277, Treponema denticola ATCC 35405 and Tannerella forsythia ATCC 43037 in the red complex pathogens for this analysis. Protein targets in the red complex organisms with optimal binding features with the herbal compound silymarin were thus identified and reported for further consideration.
Highlights
The extracts of herbs have been used for decades in traditional medicine [1]
It is of interest to identify potential targets from the red complex organisms to inhibit the herbal compound Silymarin
Workflow: It is of interest to identify potential targets from the red complex organisms to inhibit the herbal compound Silymarin
Summary
There has been an increasing interest in the study of medicinal plants and their use in different parts of the world as potent substances against various diseases [2,3,4,5,6]. 80% of the world’s human population depends on herbal medicine in the form of traditional medicine for the primary healthcare needs according to data from the World Health Organization. The development and use of medicinal plants for therapy carry considerable economic benefits in the treatment of various diseases [7]. Hepatoprotective activities, skin protection and cancer treatment using silymarin in human healthcare is known [11,12]. Data on the protective role of silymarin in prevention and treatment of oral disease such as dental caries is known [13].
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