Abstract
Periodontitis is attributed to the dental biofilm formation. Red complex organisms are a group of organisms linked with periodontal diseases. Therefore, it is of interest to identify potential targets from the red complex organisms to bind with the herbal compound resveratrol (E - 5 - (4 - hydroxy styryl) benzene 1,3 diol). We report a list of potential proteins having optimal drug like binding features with the herbal agent Resveratrol for further consideration. We used the STITCH v.5 pipeline VICMPred and VirulentPred tools to identify such targets as potential virulent factors in the red complex organisms. We considered the strains of Porphyromonas gingivalis ATCC 33277, Treponema denticola ATCC 35405 and Tannerella forsythia ATCC 43037 in the red complex pathogens for this analysis. Protein targets in the red complex organisms with optimal binding features with the herbal compound resveratrol were thus identified and reported for further consideration.
Highlights
Dental biofilm or plaque can be expressed as the community of a range of microorganisms, which are found, on a tooth surface [1,2]
The red complex pathogens include Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, which are the most important pathogens involved in the development and progression of adult periodontal disease [7]
Materials and Methods: Study design: The present study follows the planning of an observational study, which primarily aims to screen for those proteins or virulence factors of red complex pathogens, which could possibly interact with resveratrol
Summary
Dental biofilm or plaque can be expressed as the community of a range of microorganisms, which are found, on a tooth surface [1,2]. The dental plaque is found to be one of the etiological factors for the development of gingival and periodontal diseases [3]. The subgingival plaque mircobiologically consists of over 700 bacterial species, and some of these microorganisms are to be held accountable for the initiation/progression of periodontal diseases [5,6]. The red complex pathogens include Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia (formerly Bacteroides forsythus), which are the most important pathogens involved in the development and progression of adult periodontal disease [7]. There are about 92 new resveratrol compounds, which includes 39 dimers, 23 trimers, 13 tetramers, 6 monomers, 6 hexamers, 4 pentamers, and 1 octamer, all of these have been reported from the Dipterocarpaceae, Paeoniaceae, Vitaceae, Leguminosae, Gnetaceae, Cyperaceae, Polygonaceae, Gramineae, and Poaceae plant families [13]. It is of interest to identify potential targets from the red complex organisms to inhibit the herbal compound resveratrol
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