Abstract
Red complex organisms are a group of organisms (Porphyromonas gingivalis ATCC 33277, Treponema denticola ATCC 35405, Tannerella forsythia ATCC 43037) that have been identified for the causation of periodontal diseases. Aspirin and diclofenac have been used as regular analgesics. Therefore, it is of interest to document the identification of aspirin and diclofenac binding proteins in the red complex pathogens using the STITCH v.5 pipeline. The virulence properties of these proteins were analyzed using VICMPred and VirulentPred software. Thus, we document 000 number of proteins having optimal binding features with the known analgesics.
Highlights
Periodontal infection is one of the most common dental infections that occur [1] second to dental caries
Periodontitis can be defined as an inflammatory disease of supporting tissues of teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the periodontal ligament and alveolar bone with periodontal pocket formation, gingival recession or both [4]
Porphyromonas gingivalis ATCC 33277, Treponema denticola ATCC 35405, Tannerella forsythia ATCC 43037 were the strains of red complex pathogens that were utilized in this study
Summary
Periodontal infection is one of the most common dental infections that occur [1] second to dental caries. Periodontal diseases are basically bacterial infections associated with a complex microbial flora associated with that o of the dental biofilm This flora is composed predominantly of strictly anaerobic Gram-negative species that will in-turn produce a local and a systemic inflammatory response, leading to periodontal tissue destruction [5,6,7]. Only few species such as Aggregatibacter actinomycetemcomitans (A.a) and Porphyromonas gingivalis have been classically grouped as periodontal pathogens [8,9] Socransky et al showed that periodontal diseases such as gingivitis and periodontitis are associated with a group of microbes rather than individual pathogens present at the periodontal sites It comprises a consortium of three species namely, Tannerella forsythia, P. gingivalis and Treponema denticola which has been considered the most pathogenic microbial complex [5,10]. There have been various modalities of treatment of periodontitis, one of the treatment modalities is the use of therapeutic agents such as analgesics to obtain symptomatic relief, a few commonly used include aspirin and diclofenac for periodontitis [11,12]
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