Abstract
PART I: Principles of Protein Folding and Stability. Spectroscopic techniques to study protein folding and stability. Solvent effects on protein stability. Analysis of protein folding kinetics, kinetic mechanisms, transition states. Single molecule protein folding. Dynamics of unfolded polypeptide chains. Folding and stability of oligomeric proteins. Folding of membrane proteins. Molecular dynamics simulations of folding and unfolding. Ab initio methods for protein structure prediction. PART II: Protein Misfolding, Molecular Chaperones and Folding Catalysts. Methods to study aggregate formation. Amyloid diseases. Polyglutamine repeat diseases. Protein refolding technology. Engineering protein stability. Chaperone machines. Folding of nascent polypeptides. Protein assembly processes.
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