Protective properties of kefir on burn wounds of mice that were infected with S. aureus, P. auroginasa and E. coli

Songul Cetik Yildiz,Cemil Demir,Adnan Ayhanci,Mustafa Cengiz

doi:10.14715/cmb/2019.65.7.11

Songul Cetik Yildiz, Cemil Demir + Show 2 more

Open Access

https://doi.org/10.14715/cmb/2019.65.7.11

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Abstract

Burns and burn wounds are very sensitive to infections and cause a large amount of death worldwide. Although burn wound is sterile at the beginning, because of the risk factors such as prolonged hospital stay, immune suppression and burn affecting large surface area, colonisation with Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli occur. For the burn therapy, one of the most important ways is to control bacterial infections. A probiotic fermented milk product kefir has antioxidant, antimicrobial, antiinflammatory, anticancer and various health promoting features. This study aims to examine possible protective properties of kefir which was used on the burn wounds that were infected with S. aureus, P. auroginasa and E. coli. Swiss albino / Balb-c mice were seperated into four groups: (1) used as control group, (2) second-degree burn model+ burn wounds were infected with P.aeruginosa + S.aureus + E.coli, (3) second-burn wounds were treated with sterile pads dressed with kefir and (4) second-degree burn+burn wounds were infected with P. aeruginosa + S.aureus +E.coli before being treated with sterile pads dressed with kefir. The serum biochemical results verified the histopathological results and our findings showed that kefir is an effective product with cell-protecting properties.

Highlights

Burns are one of the health issues in modern life due to their serious damages to the patients and to the family relationships [1]
Swiss albino / Balb-c mice were seperated into four groups: [1] used as control group, [2] second-degree burn model+ burn wounds were infected with P.aeruginosa + S.aureus + E.coli, [3] second-burn wounds were treated with sterile pads dressed with kefir and [4] second-degree burn+burn wounds were infected with P. aeruginosa + S.aureus +E.coli before being treated with sterile pads dressed with kefir
The microorganisms causing burn infection may be infected from the environment during the treatment of patients in burn units or from another patient treated in the same unit [4,5]

Summary

Introduction

Burns are one of the health issues in modern life due to their serious damages to the patients and to the family relationships [1]. Burn area infection is a prominent problem in burn treatment and is the most common factor of fatality after burns [2,3]. Burn wound infections by Pseudomonas aeruginosa, Escherchia coli and Staphylococcus aureus are more common causes of mortality [2,6]. S.aureus that is gram-positive is the a major reason of burn wound infections [3] and commonly end up with septicaemia [7,8]. In the grampositive bacteri infected burns hyperthermia, leukocytosis, behavioral disorders, mental confusion are usually seen and around of the wound cellulitis and exuded maceration occur. Hypothermia and leukopenia are common in burn infections caused by gram negative bacteria. The patients may be confused [4]

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