Abstract
Pinus densiflora is one of the traditional medicinal plants found in the East Asia, which has a diversity of biological activities including antioxidant effect. The protective effects of a volatile extract from Pinus densiflora (VEPN) against aflatoxin B1 (AFB1)-induced oxidative stress were investigated in human hepatoma cell line, HepG2. Treatment of HepG2 with VEPN significantly reduced the levels of intracellular reactive oxygen species, thiobarbituric acid reactive substances and 8-hydroxy-2′-deoxyguanosine elevated by AFB1, but it increased the level of reduced glutathione. These results indicate that VEPN may afford cytoprotection by attenuating AFB1-induced oxidative stress.
Published Version
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