Abstract
Insulin resistance is an element of metabolic syndrome, manifested as a decrease in glucose uptake, which often leads to a variety of complications, including type 2 diabetes. Astragalin is a natural flavonoid, isolated from traditional medicinal plants, such as Cuscuta chinensis, that has been shown to exhibit a variety of pharmacological activities with anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties. However, the mechanism of astragalin on insulin resistance has not yet been elucidated. To this end, we examined the effect of astragalin on palmitic acid-induced insulin resistance in HepG2 cells. The effects of the co-incubation of PA and astragalin on the cell viability, superoxide dismutase, fat content, and markers of oxidative stress in HepG2 cells were measured. The results show that astragalin restored the cell viability, reduced oxidative stress, and insulin resistance in palmitic acid treated HepG2 cells. The protective effect of astragalin on palmitic acid-induced lipotoxicity in HepG2 cells was through inhibition of NF-was through inhibition of NF-κ and JNK signaling pathways.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
