Protective Effect of Tomato-Oleoresin Supplementation on Oxidative Injury Recoveries Cardiac Function by Improving β-Adrenergic Response in a Diet-Obesity Induced Model

Artur Junio Togneri Ferron,Dijon Henrique Salomé De Campos,Luciana Ghiraldeli,Koody Andre Hassemi Kitawara,Silmeia Garcia Zanati Bazan,Camila Renata Correa,Giancarlo Aldini,Fabiane Valentini Francisqueti-Ferron,Ana Lucia A Ferreira,Carol Cristina Vágula De Almeida Silva,Alessandra Altomare,Fernando Moreto,Jéssica Leite Garcia

doi:10.3390/antiox8090368

Artur Junio Togneri Ferron, Dijon Henrique Salomé De Campos + Show 11 more

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https://doi.org/10.3390/antiox8090368

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Abstract

The system redox imbalance is one of the pathways related to obesity-related cardiac dysfunction. Lycopene is considered one of the best antioxidants. The aim of this study was to test if the tomato-oleoresin would be able to recovery cardiac function by improving β-adrenergic response due its antioxidant effect. A total of 40 animals were randomly divided into two experimental groups to receive either the control diet (Control, n = 20) or a high sugar-fat diet (HSF, n = 20) for 20 weeks. Once cardiac dysfunction was detected by echocardiogram in the HSF group, animals were re- divided to begin the treatment with Tomato-oleoresin or vehicle, performing four groups: Control (n = 6); (Control + Ly, n = 6); HSF (n = 6) and (HSF + Ly, n = 6). Tomato oleoresin (10 mg lycopene/kg body weight (BW) per day) was given orally every morning for a 10-week period. The analysis included nutritional and plasma biochemical parameters, systolic blood pressure, oxidative parameters in plasma, heart, and cardiac analyses in vivo and in vitro. A comparison among the groups was performed by two-way analysis of variance (ANOVA). Results: The HSF diet was able to induce obesity, insulin-resistance, cardiac dysfunction, and oxidative damage. However, the tomato-oleoresin supplementation improved insulin-resistance, cardiac remodeling, and dysfunction by improving the β-adrenergic response. It is possible to conclude that tomato-oleoresin is able to reduce the oxidative damage by improving the system’s β-adrenergic response, thus recovering cardiac function.

Highlights

Clinical studies show that the excessive body fat leads to many cardiac abnormalities, among them, morphologic and functional changes [1,2]
The HSF group presented increased caloric intake, final body weight (g), adiposity index, glucose levels, HOMA-IR and systolic blood pressure values compared to the control group
The results show that the HSF groups presented with obesity, characterized by the higher values of body weight and adiposity index, and presented with obesity, characterized by the higher values of body weight and adiposity index, and metabolic syndrome, with insulin resistance, dyslipidemia, and hypertension, all diseases usually metabolic syndrome, with insulin resistance, dyslipidemia, and hypertension, all diseases usually associated with obesity [39]

Summary

Introduction

Clinical studies show that the excessive body fat leads to many cardiac abnormalities, among them, morphologic and functional changes [1,2]. Animal studies have demonstrated myocardial dysfunction in obese rodents fed with hypercaloric diets [3,4,5,6,7]. The system redox unbalance, characterized by a high production of reactive species and inefficient antioxidant activity, is one of the pathways associated with the obesity-related cardiac dysfunction [9]. The β-adrenergic system is one of the most important mechanisms responsible for myocardial contraction and relaxation [10,11,12]. Chronic expositions to reactive species are associated with sustained adrenergic stimulation, resulting in arrhythmias and heart failure [13]. Considering the redox system’s role in the pathogenesis of obesity and cardiac disorders, the use of antioxidants as therapeutic strategies has been tested [14,15]

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