Abstract
The high consumption of fat and sugar contributes to the development of obesity and co-morbidities, such as dyslipidemia, hypertension, and cardiovascular disease. The aim of this study was to evaluate the association between dyslipidemia and cardiac dysfunction induced by western diet consumption. Wistar rats were randomly divided into two experimental groups and fed ad libitum for 20 weeks with a control diet (Control, n = 12) or a high-sugar and high-fat diet (HSF, n = 12). The HSF group also received water + sucrose (25%). Evaluations included feed and caloric intake; body weight; plasma glucose; insulin; uric acid; HOMA-IR; lipid profile: [total cholesterol (T-chol), high-density lipoprotein (HDL), non-HDL Chol, triglycerides (TG)]; systolic blood pressure, and Doppler echocardiographic. Compared to the control group, animals that consumed the HSF diet presented higher weight gain, caloric intake, feed efficiency, insulin, HOMA-IR, and glucose levels, and lipid profile impairment (higher TG, T-chol, non-HDL chol and lower HDL). HSF diet was also associated with atrial-ventricular structural impairment and systolic-diastolic dysfunction. Positive correlation was also found among the following parameters: insulin versus estimated LV mass (r = 0.90, p = 0.001); non-HDL versus deceleration time (r = 0.46, p = 0.02); TG versus deceleration time (r = 0.50, p = 0.01). In summary, our results suggest cardiac remodeling lead by western diet is associated with metabolic parameters.
Highlights
Obese individuals are typically predisposed to an increased heart rate and stroke volume, which may lead to ischemic cardiomyopathy, compensatory left ventricular remodeling, non-ischemic dilated cardiomyopathy, cardiac fibrosis, and apoptosis [1]
The western diet induced changes in glucose metabolism homeostasis, characterized by higher glucose, insulin and homeostatic model of insulin resistance (HOMA-IR) compared to the control group (Table 1)
The western diet was associated with systolic and diastolic cardiac dysfunction, and remodeling at 20th week (Table 2), and changes in plasma lipid profile-higher TG, TC, non-high-density lipoprotein (HDL), and lower HDL
Summary
Obese individuals are typically predisposed to an increased heart rate and stroke volume, which may lead to ischemic cardiomyopathy, compensatory left ventricular remodeling, non-ischemic dilated cardiomyopathy, cardiac fibrosis, and apoptosis [1]. Obesity is associated with metabolic syndrome (MS), a clustering of risk factors that includes visceral obesity, dyslipidemia, hyperglycemia, and hypertension. Among these factors, dyslipidemia is the major risk factor for cardiovascular disease (CVD). WD are characterized by the consumption of high caloric-dense foods, and unbalanced proportions of fat (saturated vs unsaturated) and carbohydrates (high glycemic vs low glycemic), eating habits associated with an increased CVD risk [3]. Sonestedt et al observed that individuals with low sucrose intake had lower triglycerides and higher HDL concentrations compared to those with high sucrose consumption [2]. It has been already confirmed that the consumption of high carbohydrate foods and beverages increases the risk of MS [4]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
