Abstract
Objective Applying focal ischemia-reperfusion model of SD rat,to observe the state of neurologic impairment score, cerebral pathomorphology and infarction volume after focal ischemia-reperfusion damage in SD rat. Methods 36 healthy male SD rats ( weight from 180 g to 220 g) were randomly divided into 2 groups: control group ( n = 18 ) and aspirin + flunarizine hydrochlorid ( namely treatment group n = 18 ). Each group was divided into 3 subgroups according to reperfusion 3 h( n = 6 ) ,6 h( n = 6 ) ,24 h (n = 6 )after ischemia for 90 minutes. The changes of neurologic impairment score, cerebral infarction volume and pathomorphology were compared at the same reperfusion time. Results There are great difference of the neurologic impairment score between two groups(P ＜0.05) ,the infarction volume can be seen at treatment group. The infarction volume in the treatment group was lower than that in the control group, P ＜ 0.05. In treatment group, the injury of cerebral tissue became serious with time went by, but compared with control group, the number of neuron which became degeneration and necrosis decreased, vacuolization and intertissue edema became relieved. Conclusion Pretreatment of combination of aspirin and flunarizine hydrochlorid can decrease focal ischemia-reperfusion damage, relieve the neurologic impairment symptoms;reduce infarction volume, reduce the neuron degeneration,necrosis and tissue edma. Key words: Ischemia reperfusion; neurologic impairment; Aspirin; Flunarizine hydrochlorid
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