Abstract
BackgroundThe interaction between the PKC and oxygen free radicals. Objective and methodsThe present study examined the effects of lysophosphatidylcholine (LPC), an endogenous amphophilic lipid metabolite, on 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (OH) generation in rat striatum. LPC (50μM) increased OH formation by MPP+. Further, the effect of diltiazem, a L-type Ca2+ channel antagonist, on MPP+ (5mM)-induced OH generation was studied. ResultsDiltiazem (100μM) significantly suppressed LPC and MPP+-induced OH generation. The results indicate OH generation, and diltiazem may have preventive effect on MPP+-induced OH generation. ConclusionThese results demonstrated that diltiazem suppressed LPC-induced generation of free radical through blockage of Ca2+ channel in the rat striatum.
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