Abstract
From the ACS meeting Three research groups disclosed new protecting group techniques to the Division of Organic Chemistry. Chemists at Duke University and North Carolina State University showed protecting groups that are photolytically removable. This feature is important because multiplying the number of ways to remove protecting groups gives chemists more control over the course of a synthetic scheme. And a chemist from SynPhar Laboratories, Edmonton, Alberta, has devised a new reagent for applying the much-used methoxymethyl protecting group. Graduate student Paul B. Jones of Duke reported use of o-benzoylbenzoate esters to protect alcohols and mercaptans in work with organic chemistry professor Ned A. Porter and graduate student Mike P. Pollastri. They made the esters by reaction of a thiol or primary or secondary alcohol with o-benzoylbenzoic acid and dicyclohexylcarbodiimide (DCC), catalyzed by p-dimethylaminopyridine (DMAP) in pyridine solvent. They remove the group by photolysis in various solvent...
Published Version
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