Abstract
Objective To study the effects of weight change on blood sugar in obesity adult in servern years to explore the role of body weight in the blood suger. Methods A severn years follow-up study was con-ducted in the 583 simple obesity adult(BMI≥25 kg/m2) who were chosen in 2000-2001 and were divided into three groups rely on body weight change. Before and after follow-up adiposity, weight、fasting plasma glucose (FPG) , fasting insulin (FIns) and 2 h blood glucose (2 hPG) were measured. , while insulin resistance index (HOMA-IR) and endothelial dysfunction (EDD)were caeulated. Results 524 of 583 subjects were followed up in 2007,the average of FPG、2 hPG were significant higher than those of the former,while EDD were de-creased. Meanwhile the weight gain group have higher changes of FPG、PBG、HOMA-IR、EDD than those with weight loss group and constant weight group,in control of age, sex, the partial correlation analysis showed that: Baseline weight, BMI, and follow-up weight (BMI) changes have positively correlated with FPG, PBG. △BMI and △BG has a significant linear relationship. Conclusion The increased weight has closely relationship with high blood sugar and EDD. Effective weight control is one of the most effective means to prevent the occurring of DM in obese subjects. Key words: Obesity; Weight change; Blood suger. ; Endothelial dysfunction
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