Abstract
Prolactin-releasing peptide (PrRP) is found as an endogenous ligand of G-protein-coupled receptor (hGR3/UHR-1/GPR10) which is highly expressed in the anterior pituitary gland. PrRP and PrRP receptor mRNA are expressed in the brain and some peripheral tissues. In addition, PrRP positive neurons are localized in A1 and A2 noradrenalin cells in the medulla oblongata and in the dorsomedial nucleus of the hypothalamus. In addition to prolactin release, PrRP has various functions in the central nervous system, such as regulating the hypothalamic–pituitary–adrenal axis and mediating stress responses, food intake regulation, blood pressure, and the opioid system.
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