Progression of pulmonary tumor in mice. 1. Histological studies of primary and transplanted pulmonary tumors.

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Histological and biological observations were carried out on pulmonary tumors in mice which arose in the following four series of experiments: 1) pulmonary tumors in A/Jax and DD strain of mice which developed spontaneously or were induced by a single injection of 3‐methylcholanthrene or 4‐nitroquinoline‐n‐oxide, 2) transplanted pulmonary tumors in the first and second transfer generations, 3) tumorous growth which developed in subcutaneously transplanted lung tissues, and 4) serially transplanted pulmonary tumors in five established lines.The pulmonary tumor in mice was considered as a progressive tumor and the varieties of histology were classified into five or eight types on the basis of relationship between the histological features and the biological activities. The idea of the progression from benign to malignant stage was presented in the pulmonary tumors in mice by the author for the first time.