Abstract
By subcutaneous serial transplantations of induced pulmonary tumors of mice a tumor progression has previously been correlated with the age of the tumors. The progression showed alterations from an alveolar-lining-type adenoma through papillary structures and different carcinomas to a spindle cell carcinoma in the final stage. Based on this report, 448 spontaneous pulmonary tumors in conventional and specific-pathogen-free Han: NMRI mice in different stages of life were classified. Six different types of pulmonary tumors were identified and compared with the age of the host. With increasing age of the host the pulmonary tumor tends to develop towards ultimate malignancy. Such a time-dependent transformation occurs regularly, as shown by a statistical analysis. A progression of primary spontaneous pulmonary tumors in mice is indicated as well.
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