Progress of platelet-rich plasma in diabetic foot disease therapy

Abstract

Diabetic foot are chronic refractory wounds that pose a major health burden to society. Numerous advanced treatment options for the management of diabetic foot have been explored, including bioengineered skin substitutes, hyperbaric oxygen therapy and negative pressure dressings. However, the effective therapies are still lacking. Platelet-rich plasma (PRP) is rich in platelet, white blood cells, growth factors and other components. It has the characteristics of promoting wound repair, reducing wound pain, sealing and protecting wounds and inhibiting local bacterial growth that has a definite effect in the application of diabetic foot therapy. With the gradual maturity of the therapy of PRP, the use of PRP will be the most promising treatment for diabetic foot. Key words: Platelet-rich plasma; Diabetic foot; Chronic wounds