Clinical study on the effect of hyperbaric oxygen combined with liposomal alprostadil in the treatment of diabetic foot

Abstract

Objective To study the clinical effect of hyperbaric oxygen (HBO) combined with liposomal alprostadil (Lipo-PGE1) in the treatment of diabetic foot.Methods Ninety patients with diabetic foot were randomly divided into the study group (HBO + liposomal alprostadil),the HBO group and the liposomal alprostadil group,each consisting of 30 cases.The patients of the 3 groups all received routine treatment,such as diabetic diet,hypoglycemic agent,trophic nerve and wound surface management.In addition to the routine treatment mentioned above,the patients in the study group received 20 μg intravenous drip diluted with 100 ml saline solution,once a day.At the same time,they had HBO therapy at a pressure of 0.2 MPa,once a day,10 sessions a treatment course.In addition to the same routine treatment,the HBO group received HBO therapy also at a pressure of 0.2 MPa,once a day,10 sessions a treatment course.With the same routine treatment mentioned above,the liposomal alprostadil group only received 20 μg intravenous drip diluted with 100 ml saline solution,once a day.After 4 treatment courses,therapeutic effects on the patients of the 3 groups were evaluated respectively.Results Following treatment,total effective rates for the study group,the HBO group and the liposomal alprostadil group were 93.3％,76.7％ and 70.0％ respectively.Significant differences in therapeutic effects could be noted,when the former was compared with the latter two groups (P ＜ 0.05).Conclusions In the treatment of diabetic foot,HBO coupled with liposomal alprostadil could improve blood and oxygen supplies to the lower limbs,enhance microcirculation,increase healing rate of ulcers,and it was surely an effective treatment strategy for the treatment of diabetic foot. Key words: Hyperbaric oxygen; Liposomal alprostadil; Diabetic foot; Clinical effect