Effects of autologous bone marrow stem cell transplantation coupled with hyperbaric oxygen in the treatment of 44 cases of diabetic foot ulcer

Abstract

Objective To observe the therapeutic effects of autologous bone marrow stem cell transplantation coupled with HBO in the treatment of diabetic foot ulcer. Methods Autologous bone marrow stem cell transplantation was performed on 88 patients with diabetic foot ulcer, of whom 44 were treated with hyperbaric oxygen (HBO), and the treatment results were compared with those of the control group, and then, therapeutic effects were observed closely. Results Following treatment, such clinical data as limping, pain in the affected limb, sensation of cold, skin temperature, TcPO2 and ankle/brachial index (ABI) were all alleviated dramatically. After treatment, such data as epidermal growth factor (EGF)[control group: (151.4±5.11)ng/L, HBO group: (171.2±5.69)ng/L], platelet derived growth factor (PDGF)[control group: (79.36±6.24)ng/L, HBO group: (90.80±10.31)ng/L], thromboxane B2 (TXB2)[control group: (129.34±14.86)ng/L, HBO group: (104.15±15.26)ng/L] and 6-K-PGF1α[control group: (78.93±15.98)ng/L, HBO group: (91.15±16.27)ng/L] all improved obviously, and the therapeutic effects of the HBO group were significantly superior to those of the control group. Conclusions Autologous bone marrow stem cell transplantation coupled with HBO could produce good clinical effects in the treatment of diabetic food ulcer. Key words: Stem cell transplantation; Hyperbaric oxygen; Diabetic foot; Ulcer