Abstract
MicroRNAs (miRNAs), 19~24 nucleotides in length, are single-stranded conserved endogenous small non-coding RNA molecules that regulate gene expression at post-transcriptional level by inhibiting target mRNA translation or degrading mRNAs via specific hybridization to complementary sequences of their target genes. Emerging evidence has demonstrated that miRNAs are closely related to a variety of human autoimmune diseases. Myasthenia gravis (MG) is an autoimmune disorder caused by impaired transmission at the neuromuscular junction. Exploring molecular mechanisms in association with miRNA involvement in the generation of MG could contribute to clarifying the pathogenesis of MG and provide a solid basis for molecular diagnosis and individual treatment of MG. In this review, we summarize the advances in the research on the correlation between miRNAs and MG. Key words: microRNA; Autoimmune disease; Myasthenia gravis
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