PROGNOSTIC VALUE OF THE EXPRESSION OF ENDOGENOUS HYPOXIA ASSOCIATED PROTEINS HYPOXIA INDUCIBLE FACTOR-1 ALPHA (HIF-1Α) AND CARBONIC ANHYDRASE ISOFORM 9 (CAIX) EXPRESSIONS IN BREAST CARCINOMA.

Olaa Harb,Amalma Adim,Loaym Gertallah,Sharifaamel Ammari,Ibtesam Elhasadi,Fadym Habib,Basantshel Shafaay,Wardam Said

doi:10.21474/ijar01/6516

Abstract

10Feb 2018 PROGNOSTIC VALUE OF THE EXPRESSION OF ENDOGENOUS HYPOXIA ASSOCIATED PROTEINS HYPOXIA INDUCIBLE FACTOR-1 ALPHA (HIF-1) AND CARBONIC ANHYDRASE ISOFORM 9 (CAIX) EXPRESSIONS IN BREAST CARCINOMA. Ola A. Harb , Ibtesam Elhasadi , Amal M A Adim , Warda M Said , Sharifa A. M. El.Ammari , Basant Sh El Shafaay Fady M. Habib and Loay M. Gertallah. Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt. Department of Pathology, Faculty of Medicine, Benghazi University, Benghazi, Libya. Department of Clinical Oncology and nuclear medicine, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt. Department of General surgery, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.

Highlights

HIF-1α and carbonic anhydrase IX (CAIX) positive expression in breast carcinoma was related to advanced stage, presence of lymph node metastases, HER2 amplified and triple negative molecular subtypes (p
CAIX expression, correlation to clinical and histopathological findings Tables 2 &3; fig 2 The positive expression of CAIX in breast carcinoma was significantly correlated with older age of the patients, advanced stage of the tumor, aggressive molecular type, presence of lymph node metastases, high KI67 index, aggressive molecular subtypes as HER2 amplified and triple negative subtypes, (p
Our present results detected that when HIF-1α positively expressed in breast carcinoma that will be significantly related to worse clinic pathological findings like older age of the patients, higher grade and advanced stage of the tumor, aggressive molecular subtypes, presence of LN and distant metastasis, we found that cases with positive HIF-1α expression had a higher rate of carcinoma recurrence, poor RFS and 3 year OS rates

Summary

Introduction

CAIX expression, correlation to clinical and histopathological findings Tables 2 &3; fig 2 The positive expression of CAIX in breast carcinoma was significantly correlated with older age of the patients, advanced stage of the tumor, aggressive molecular type, presence of lymph node metastases, high KI67 index, aggressive molecular subtypes as HER2 amplified and triple negative subtypes, (p

Results

Conclusion