CAN RESECTION OF LIVER METASTASIS IMPROVE SURVIVAL AFTER RESECTABILITY CONVERSION CHEMOTHERAPY IN PATIENTS WITH METASTATIC COLO-RECTAL CANCER

Ahmed A Alnagar,Morsi Mohamed,Wael Mansy,Lobna A Abdelaziz,Alaa A Farag

doi:10.21474/ijar01/153

Abstract

30Apr 2016 CAN RESECTION OF LIVER METASTASIS IMPROVE SURVIVAL AFTER RESECTABILITY CONVERSION CHEMOTHERAPY IN PATIENTS WITH METASTATIC COLO-RECTAL CANCER? Ahmed A Alnagar , Wael mansy , Morsi Mohamed , Alaa A Farag and Lobna A. Abdelaziz. Medical Oncology Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt. General Surgery department, Faculty of Medicine, Zagazig University, Sharkia, Egypt. Internal Medicine Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt. Clinical Oncology Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt.

Highlights

Colon-rectal cancer is the fourth most frequent cancer worldwide, 35%-50% develop metastasis, 60%- 80% of them have unresectable liver metastasis, 20% to 34% present with synchronous liver metastasis, while the others are metachronous, only 15%-20% will be candidate for hepatectomy, While chemotherapy can convert around 10% to resectability, R0 surgical resection leads to improvement in median 5-years survival in patients with resected liver metastasis
The median OS was not reached in the resected group The estimated mean OS for the unresectable group was 15.7±0.96(95% CI 13.8-17.6) compared to 20.1±1.24(95% CI 17.7-22.6) in the resected group that is statistically significant different withp-value 0.015
Conclusion:chemotherapy can help in resectability conversion of unresectable liver metastasis

Summary

RESEARCH ARTICLE

CAN RESECTION OF LIVER METASTASIS IMPROVE SURVIVAL AFTER RESECTABILITY CONVERSION CHEMOTHERAPY IN PATIENTS WITH METASTATIC COLO-RECTAL CANCER?. Ahmed A Alnagar1,Wael mansy[2], Morsi Mohamed[2], Alaa A Farag[3], Lobna A. 1. Medical Oncology Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt. 2. General Surgery department, Faculty of Medicine, Zagazig University, Sharkia, Egypt. 3. Internal Medicine Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt. 4. Clinical Oncology Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt

Background

Results

CEA mean St deviation Range mean St deviation Range

Left lateral hepatectomy