Abstract
30Jan 2017 PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF PROGRAMMED DEATH LIGAND (PD-L1) AND FOXP3 EXPRESSIONS IN TUMOR CELLS AND TUMOR MICROENVIRONMENT IN OVARIAN CANCER PATIENTS Lobna A. Abdelaziz , Shereen El Shorbagy , Ola M Elfarargy , Ola A. Harb , and Abeer M Abdelbary. Clinical Oncology and Nuclear Medicine Department , Faculty of Medicine, Zagazig University. Medical Oncology Department, Faculty of Medicine, Zagazig University. Pathology Department, Faculty of Medicine, Zagazig University.
Highlights
The microenvironment of epithelial ovarian cancerReceived: 29 November 2016 Final Accepted: 26 December 2016 Published: January 2017(EOC) continued to be an important point of research to discover new therapeutic targets for such malignancy
It was discovered that any cells that were in the microenvironment of the Epithelial ovarian cancer (EOC) may be associated with cancer prognosis like tumor-infiltrating lymphocytes (TILs) and T
The expressions of programmed death ligand 1 (PD-L1) and FOXP3 in both tumor cells and stromawere evaluated in sections of 50 paraffin blocks that were retrieved from 50 patients with EOC using immunohistochemistry.We assessed the relation between their expressions, clinicopathological parameters, survival and prognosis of those patients
Summary
Received: 29 November 2016 Final Accepted: 26 December 2016 Published: January 2017. (EOC) continued to be an important point of research to discover new therapeutic targets for such malignancy. It was discovered that any cells that were in the microenvironment of the EOC may be associated with cancer prognosis like tumor-infiltrating lymphocytes (TILs) and T-. Epithelial ovarian cancer, microenvironment; PD-L1; FOXP3; prognosis regulatory cells (Tregs). Tregs (mature T lymphocytes) that start in the thymus after stimulation of naïve T cells and responsible for the reduction of autoimmune diseases, but its over production will inhibit endogenous protection against infection and tumors. It was found that Foxp is found in Treg cells that originated in the thymus and in malignant cells and its difference in expression can affect the outcome of cancer patients. Aim of our study: was to assess PD-L1 and FOXP3 expression in epithelial ovarian carcinoma a trial to detect their prognostic value and their impact on survival in patients with such type of cancer
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