Progesterone treatment of threatened abortion, maternal serum levels of progesterone-induced blocking fac-tor and its clinical significance

Abstract

Objective To investigate the treatment of threatened abortion progesterone maternal serum pro-gesterone-induced blocking factor(PIBF)levels and clinical significance, in order to be able to provide theoretical references of progesterone treatment of threatened abortion. Methods Threatened abortion women(study group)and non-threatened abortion women(control group),50 patients in the observation group given progesterone therapy, enzyme-linked immunosorbent assay(ELISA)was used to detect serum progesterone and PIBF levels of the obser-vation group before treatment and two weeks later, the control group was selected and named after two weeks. Results Observation group after treatment 47 patients progesterone tocolysis successful, success rate was 94.00%, tocolysis bleeding stop time 8.42d, abdominal pain time 11.32d.PIBF of the observation group was(313.52±90.43)mmol／L, which was lower than that of the control group(398.47±104.25)mmol／L, the difference was statistically significant (t＝10.90,P＜0.05). The progesterone of the observation group after 2 weeks of treatment was(92.35±20.85)mmol／L, which was higher than that before treatment(74.49±14.22)mmol／L, compared with progesterone levels of the con-trol group at the same time(83.26±20.14)mmol／L and(78.05±15.38)mmol／L, the difference was statistically significant(t＝7.96,8.11,P＜0.05),PIBF after 2 weeks of treatment in the observation group was(510.73± 87.49)mmol／L, which was higher than that of the control group at the same time(498.26±69.88)mmol／L, the difference was statistically significant(t＝4.35,P＜0.05).Follow-up observation group miscarriage successful term delivery rate 95.74%of pregnant women, childbirth fetal malformations seen in the control group of pregnant women at term birth rate was 94.00%, no delivery fetal malformation, the difference of full-term delivery rate was not statis-tically significant(P＞0.05). Conclusion Reduced PIBF during early pregnancy may be one of the reasons of threatened abortion, the use of progesterone therapy can increase PIBF expression, possibly through this pathway plays a role in tocolysis, so when using progesterone tocolysis monitoring PIBF levels helps evaluate the efficacy of tocolysis. Key words: Abortion, Threatened; Progesterone-induced blocking factor; Progesterone