Abstract
Background. Toxoplasma gondii is an obligate intracellular protozoan parasite and is a major opportunistic pathogen in immune-compromised hosts. This study assessed the prevalence of T. gondii and associated risk factors among people living with HIV. Methods and Materials. A cross-sectional study was carried out among people living with HIV attending Gondar University Hospital. A structured and pretested questionnaire was used to collect sociodemographic factors, and 10mL of venous blood was collected for anti-Toxoplasma antibody test and determination of CD4 levels. Serum was tested in duplicate for anti-Toxoplasma antibody using rapid slide agglutination test. Results. A total of 170 study subjects were enrolled in the study. Seroprevalence of T. gondii among the study participants was 76.5% (95% CI: 69.0–82.8). High proportions of seropositive individuals (64.7%) were found under the child bearing age groups. The mean CD4+ lymphocyte count of HIV monoinfected participants was cells/mm3 while coinfected study participants had mean CD4+ lymphocyte count of cells/mm3 with value of 0.01. Conclusion. The seroprevalence of T. gondii among people living with HIV was high. Cautious followup of HIV-positive patients is needed to prevent development of toxoplasmic encephalitis and other related complications.
Highlights
Toxoplasma gondii is an obligate intracellular protozoan of worldwide distribution and is a major opportunistic pathogen in immunocompromised hosts
This study assessed the prevalence of T. gondii and associated risk factors among people living with HIV
The seroprevalence of T. gondii among people living with HIV was high
Summary
Toxoplasma gondii is an obligate intracellular protozoan of worldwide distribution and is a major opportunistic pathogen in immunocompromised hosts. Toxoplasmosis in patients with AIDS is usually the result of reactivation of latent infection. In HIV-positive people, without previous exposure to T. gondii, the acute infection could not be well controlled and in these susceptible hosts a wide range of infections is expected [2]. Toxoplasma gondii is an obligate intracellular protozoan parasite and is a major opportunistic pathogen in immunecompromised hosts. This study assessed the prevalence of T. gondii and associated risk factors among people living with HIV. A cross-sectional study was carried out among people living with HIV attending Gondar University Hospital. Seroprevalence of T. gondii among the study participants was 76.5% (95% CI: 69.0–82.8). The seroprevalence of T. gondii among people living with HIV was high. Cautious followup of HIV-positive patients is needed to prevent development of toxoplasmic encephalitis and other related complications
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
