Abstract
The pelvic floor muscle (PFM) is a critical structure maintaining the support system of pelvic organs, primarily composed of the anal support belt. Structural abnormalities and functional disorders may lead to clinical pathological changes, resulting in pelvic floor dysfunction (PFD), significantly impacting patient health. To address the challenges in PFD treatment, we first constructed a novel Zn4L2 (phen)4 for drug delivery and characterized its structure and fluorescence properties. Subsequently, we developed a stable and biocompatible drug, MOFs@SiO2 nanoparticles, loaded with Oxybutynin. Detailed characterization of their structure was performed. An in vitro cellular model of PFD was established through mechanical injury, and our synthesized novel Zn4L2 (phen)4@SiO2-Oxybutynin particles successfully alleviated the induced upregulation of MDA and downregulation of GPX4 associated with PFD, demonstrating the particle's efficacy in treating PFD by regulating ferroptosis. This study highlights the significant potential of this novel preparation strategy in the biomedical field.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call