Preparation of New Complexes of Fe(II), Co(II), Ni(II) and Cu(II) with Mixed Ligands of Ciprofloxacin or Levofloxacin with Eugenol and Study of Their Chemical and Physical Properties

Abstract

Eight new mixed ligands metal complexes have been prepared by the reaction of Fe(II), Co(II), Ni(II) and Cu(II) with (1:1:1 molar ratio) of ciprofloxacin - eugenol or levofloxacin - eugenol mixed ligands in alkaline medium. The coordination of the mixed ligands toward metal ions has been anticipated in the light of elemental analysis, molar conductance, spectral infrared (IR), ultraviolet-visible (UV-Vis) and magnetic measurments were bidentate ligands. Electronic and magnetic data suggested the octahedral configuration for all these new complexes. The molar conductance data for the metal complexes show non-electrolytic behavior in DMF solvent and non-electrolytic properties, also they were no conducting electrical current.The biological activity of the prepared complexes was studied with positive and negative Gram-positive bacteria and good antibacterial results.