SYNTHESIS, PHYSICOCHEMICAL AND ANTIOXIDANT PROPERTIES OF SOME METAL(II) COMPLEXES OF MIXED DRUGS, ASPIRIN AND NICOTINAMIDE.

Aderoju Osowole

doi:10.15436/2475-6245.16.010

Abstract

The Drugs, Aspirin (HL) and Nicotinamide (HL3), and their mixed metal(II) complexes were synthesized and isolated as [M(HL)(HL3)X2], where M = Fe, Co, Ni, Cu, Zn; X = Cl-/SO42-. These complexes were characterized by spectroscopic techniques (IR & UV-Visible), percentage metal, molar conductance, melting point and room temperature magnetic moment measurements. The metal complexes were mostly non-electrolyte in DMSO with molar conductance values in the range 19.70 - 46.80 Ω-1cm2mol-1. Nicotinamide and Aspirin behaved as bidentate, coordinating to the metal ion through their carbonyl oxygen and pyridinyl nitrogen atoms respectively, as corroborated by infrared spectroscopy measurement. Electronic spectra indicated that all the metal complexes adopted octahedral geometry and magnetic data revealed that the Mn(II) and Ni(II) complexes were probably dimeric, while the remaining metal complexes were monomeric, diamagnetic or paramagnetic. In addition, the antioxidant study revealed that the drugs, Aspirin and Nicotinamide (Vitamin B3), and their mixed metal complexes had higher antioxidant activity than Ascorbic acid, the positive standard, thus confirming their potentials as anticancer agents in-vitro.

Highlights

Drug-metal complexes are of interest due to their various medicinal applications e.g. Paul Erich’s organoarsenic compound for the treatment of syphilis, anti-arthritic gold preparations, and diagnostic agents for magnetic resonance imaging (Gd, Mn, Fe) and many others[1]
We envisaged that the synthesis of these mixed drug metal(II) complexes of Aspirin and Nicotinamide, would lead to novel chemotherapeutics with very good antioxidant properties as reported by some authors on metallo-antibiotics and metallo-antimalarias[10,11,12]
We present our findings on the synthesis, characterization and antioxidant properties of these metal(II) complexes of the mixed-drugs, Aspirin and Nicotinamide as a continuation of our search for novel metallo-drug complexes as lead compounds in drug research[19,20,21,22,23,24]

Summary

Introduction

Drug-metal complexes are of interest due to their various medicinal applications e.g. Paul Erich’s organoarsenic compound for the treatment of syphilis, anti-arthritic gold preparations, and diagnostic agents for magnetic resonance imaging (Gd, Mn, Fe) and many others[1]. We envisaged that the synthesis of these mixed drug metal(II) complexes of Aspirin and Nicotinamide, would lead to novel chemotherapeutics with very good antioxidant properties as reported by some authors on metallo-antibiotics and metallo-antimalarias[10,11,12]. We present our findings on the synthesis, characterization and antioxidant properties of these metal(II) complexes of the mixed-drugs, Aspirin and Nicotinamide as a continuation of our search for novel metallo-drug complexes as lead compounds in drug research[19,20,21,22,23,24]. The reagent used contained 1 mL of 10 mM CuCl2.2H2O, 1 mL of 7.5 mM, 1, 10- phenanthroline and 1 mL of 1M ammonium acetate This solution was added to a test-tube containing 0.6 mL of distilled water and 0.5 mL of sample solution with the same concentration (0.01g/mL methanol) to achieve a final volume of 4.1 mL.

Results and Discussion

Mass Color

Conclusion