Abstract
Three novel mixed ligand metal complexes have been synthesized by the reaction of Zn(II), Sn(II), and Ce(III) with gemifloxacin (GMFX) in the presence of glycine (Gly) (1:1:1 molar ratio). The coordination possibility of the two ligands toward metal ions has been proposed in the light of elemental analysis, molar conductance, spectral infrared (IR), ultraviolet-visible (UV-Vis) and proton-nuclear magnetic resonance (1H NMR), and magnetic studies. Results suggest that GMFX and Gly interact with the metal ions as bidentate ligands. Electronic and magnetic data proposed the octahedral structure for all complexes under investigation. Antibacterial screening of the compounds was carried out in vitro against two Gram-positive bacteria, Clavibacter michiganensis and Bacillus megaterium, and two Gram-negative bacteria, Escherichia coli and Xanthomonas campestris. Antifungal activity was performed in vitro against Rhizoctonia solani, Sclerotinia sclerotiorum, Aspergillus niger, Botrytis cinerea, and Penicillium digitatum. The ligands and their complexes were also screened for their antioxidant activity. Results showed that some metal complexes showed more biological efficiency than the parent GMFX drug.
Highlights
Quinolones are a group of synthetic antibacterial agents used in treatment of many infections [1,2,3].Fluoroquinolone gemifloxacin (GMFX) (Scheme 1A) is a synthetic broad-spectrum antibacterial agent [4] used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia
From this point of view, diverse metal complexes with fluoroquinolones have been synthesized in an attempt to investigate the physicochemical properties and evaluate their biological properties [10,11]
The complexes were obtained as colored powdered materials
Summary
Quinolones are a group of synthetic antibacterial agents used in treatment of many infections [1,2,3]. The metal complexes of drugs are more active than the parent compound [8,9] From this point of view, diverse metal complexes with fluoroquinolones have been synthesized in an attempt to investigate the physicochemical properties and evaluate their biological properties [10,11]. The biological characterization of GMFX and its synthesized metal complexes was carried out by by an antifungal activity test activity against some phytopathogenic fungi such as; Rhizoctonia solani an antifungal activity test activity against some phytopathogenic fungi such as; Rhizoctonia solani J.G. J.G. Kühn., Sclerotinia sclerotiorum (Lib.) de Bary., Aspergillus niger van Tieghem., Botrytis cinerea Pers., Kühn., Sclerotinia sclerotiorum (Lib.) de Bary., Aspergillus niger van Tieghem., Botrytis cinerea Pers., and and Penicillium digitatum Sacc. (3-ethylbenzthiazoline-6-acid) (ABTS) for determine the radical scavenging activity (RSA%)
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