Abstract
An efficient synthesis of new aminodimethyl(methylsulfonyl)dihydropyrido[2,3-d]pyrimidinedione derivatives via the three components reaction of 2-methanesulfonylacetonitrile, 1,3-dimethyl-6-amino-uracil, and aromatic aldehydes in the presence of [HO-(CH2)2-NH2][CH3CO2H] and Fe3O4@SiO2@[O-(CH2)2-NH2][CH3CO2H] as novel heterogeneous magnetic nanocatalyst was described. The Fe3O4@SiO2@[O-(CH2)2-NH2][CH3CO2H] as nanocatalyst can be easily separated from the reaction mixture by an external magnet, recycled, and reused several times without any significant decrease in catalytic activity. These methods showed several advantages, including high yields, easy operation, and environment-friendly protocols.
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