Preparation of Gel-Formed Dachuanxiong Prescription Delivered through Nasal Mucosa

Abstract

Purpose: Preparation of gel-formed Dachuanxiong prescription. Method: In this experiment, liquid chromatograph is used to measure the content of gastrodin in gastrodia elata and orthogonal design method is adopted to optimize the technological conditions for extracting gastrodin. Comprehensive evaluation is conducted based on examination factors including dry powder, glycerol, hydroxypropyl methylcellulose and borneol as well as indexes including viscosity, appearance and spreadability, through which prescription can be screened and optimized, and gel-formed Dachuanxiong prescription can thus be prepared. Result: Content of gastrodin in gastrodia elata as raw material is 0.53%, and excipient should be gel made from 1 g of ethanol, 1.5 g of hydroxypropyl methylcellulose, 10 g of glycerol, 0.01 g of borneol and 100 g of water. Conclusion: This technology for preparation of gel is stable and simple, which can increase the content of ferulic acid obviously. Preparation of pure traditional Chinese medicine is delivered through nasal mucosa to relieve headache and mainly used to treat headache.[1]Chuanxiong Prescription was established by Liu Wansu, a well-known doctor living in the Jin and Yuan Dynasty. In this prescription, ligusticum wallichii can invigorate the circulation of blood and promote the circulation of qi, and gastrodia elata can relieve dizziness and pain. Combination of them can realize a good effect for the treatment of migraine caused by blood stasis and fire. This prescription is simple and effective. Based on physical and chemical properties of various medical materials, active ingredients in them can be extracted with the method of alcohol extraction. [2-4]According to result of document retrieval and patent search, volume fraction, number of times of extraction and time of extraction should be used as conditions of examination. [1]However, it can be verified through in-depth research on physical and chemical properties and pharmacological actions of medical materials in the prescription as well as repetitive tests that number of times of extraction have an obvious influence on extraction rate. Based on the above content, factors of examination in the experiment are determined and examination through orthogonal experiment is thus carried out, through which technological conditions that can realize a high rate of extraction of gastrodin (index component) is screened out. This experiment selects the optimal technology for extracting gel which can relieve headache and be delivered through nasal mucosa, in which orthogonal test method is applied, and content of gastrodin is viewed as an index. Ethanol should be used in the optimal extraction technology. The optimal technology is stable and practicable, which can obviously increase the content of ferulic acid.