Preparation of a Fluorous Chiral BINOL Derivative and Application to an Asymmetric Protonation Reaction

Abstract

Fluorous Chiral Proton Source ( R, S)-FDHPEB resulted in a higher enantioselectivity (95% ee) than that of the original nonfluorous ( R, S)-DHPEB (87% ee) in an enantioselective protonation of a samarium enolate. ( R, S)-FDHPEB was easily recovered by a simple filtration through a fluorous reverse phase silica gel and was recyclable.