Fluorous Methods for Synthesis and Separation of Organic Molecules: From Separating Mixtures to Making Mixtures

Abstract

Fluorous molecules partition out of an organic phase and into a fluorous (highly fluorinated) phase in a liquid-liquid extraction. New fluorous techniques allow simple yet substantive separations of organic reaction mixtures based on the presence or absence of a fluorous tag. Fluorous-tagged molecules can also be separated from non-tagged molecules by solid phase extraction over fluorous reverse phase silica gel. This technique is ideal for solution phase parallel synthesis because it allows simple yet substantive separations of organic reaction mixtures.