Fluorous Reverse Phase Silia Gel. A New Tool for Preparative Separations in Synthetic Organic and Organofluorine Chemistry

Abstract

Fluorous reverse phase silica gel, or silica gel with a fluorocarbon bonded phase, can be readily prepared by standard techniques, but shows unusual separation features. This silica gel separates primarily by fluorine content. Uses of fluorous reverse phase silica gel in both synthetic organic chemistry and organofluorine chemistry are introduced. Solid phase extraction can be used to separate fluorous or fluorous-tagged compounds from organic compounds. Fluorous chromatography can be used to purify mixtures of compounds with differing fluorine content as well as for "demixing" in the new technique of fluorous mixture synthesis.