Abstract
A novel method for preparation of 3-allenyl-4-methylene-tetrahydrofurans was disclosed via Pd-catalysed enyne cyclization reaction of propargyl 2-en-4-ynyl ether under Suzuki coupling conditions. The reaction proceeds via Pd-activation of the terminal alkyne, cyclization, formation of allenyl moiety, and reductive elimination leading the final product. This methodology offers several advantages such as easy manipulation, mild reaction conditions, and easily accessible starting materials, providing a range of tri- and 1,1-di-disubstituted allenyl methylenefuran derivatives.
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