Abstract
Purpose : To synthesize and characterize eco-friendly gold nanorods (Au-NRs) and to assess their effects against two bacterial strains. Methods : Synthesis of eco-friendly gold nanorods was done from an aqueous solution of chloroauric acid and cetyltrimethylammonium bromide by mixing Olea europaea fruit and Acacia nilotica husk extracts with the latter as a reducing agent. The synthesis was monitored by ultraviolet–visible (UV) spectrophotmetry and a zetasizer, while the morphology of the resulting nanorods was assessed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) coupled with an energy-dispersive spectrophotometer (EDS). The effect of the prepared eco-nanorods on growth of Escherichia coli and Staphylococcus aureus bacteria were investigated by agar diffusion method. Results : The synthesized Au-NRs were mostly rod-shaped, with mean size of 96 nm. They exhibited a potent antibacterial activity against Gram-positive and Gram-negative microorganisms ( Escherichia coli and Staphylococcus aureus ). Conclusion : The findings suggest that the nanoformulation of the biomaterial mix of Olea europaea fruit and Acacia nilotica husk extracts is a cost-effective, eco-friendly, and non-toxic synthesis of Au- NRs which has therpeautic potential. Keywords : Olea europaea, Acacia nilotica, Gold nanorods , Eco-friendly synthesis, Gram-positive and Gram-negative microorganisms
Highlights
Nanotechnology is a science that involves the manipulation of matter at the atomic and molecular levels
Biological synthesis elucidates the importance of metal-microbe interaction in several biotechnological applications, including bioremediation, biomineralization, bioleaching, and microbial corrosion [2]
The key findings of the present study include an eco-friendly synthesis of Au-NRs using cetyltrimethylammonium bromide (CTAB) as a surfactant and a mixture (1:3) of Olea europaea fruit extract and Acacia nilotica husk extract. can be achieved, The technique used is simple and cost-effective, and does not involve the use of toxic chemicals
Summary
Nanotechnology is a science that involves the manipulation of matter at the atomic and molecular levels. Nanobiotechnology is an integral and emerging tool for engineering ecofriendly nanoscale materials using natural biological sources [1]. The integration of inorganic nanoparticles (NPs) and biological structures is one of the most challenging areas of research. Biological synthesis elucidates the importance of metal-microbe interaction in several biotechnological applications, including bioremediation, biomineralization, bioleaching, and microbial corrosion [2]. NPs are unique in having a high surface area-tovolume ratio and high percentage of atoms at the grain boundaries [3,4]. Biological processes do occur at the nanoscale, which accounts for the ease of application of NPs in the field of medicine because of their amenability to biological functionalization [5]. The latter have gained significant importance EXPERIMENTAL because of their ability to resist the processing conditions [6]
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