Abstract
Temperature sensitive hydrogels are probably the most commonly studied class of environmentally sensitive polymer systems in drug delivery research. In this study, polyvinyl alcohol (PVA) matrix with nanosized pores was obtained by treatment with silica and glutaraldehyde. Then, the internal pores of the dry PVA matrix were filled with poly(N-isopropylacrylamide) (PNIPAAm) hydrogels to form a thermoresponsive hybrid PVA/PNIPAAm hydrogel for controlled drug release. The morphology and functional groups of the hybrid hydrogel were characterised by SEM and Fourier transform infrared spectroscopy. The swelling kinetics and the temperature dependence of equilibrium swelling ratio in distilled water were also investigated. Rhodamine B was loaded to the hybrid hydrogels for release study, and the release rate was fast when the temperature was above the lower critical solution temperature of PNIPAAm. The release data suggest that an excellent controlled release can be achieved by the hybrid hydrogel without losing the intelligent properties of the PNIPAAm hydrogel.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
