Abstract
The interaction of ciprofloxacin with HP-β-cyclodextrin (HP-β-CD) has been studied by several analytical techniques, including 1 H nuclear magnetic resonance (NMR), 13 C NMR, fluorescence spectra, infrared spectroscopy, thermal analyzer and scanning electron microscope. In this paper, solid inclusion complex of ciprofloxacin with HP-β-CD was synthesized by the coprecipitation method. In addition, the characterization of the inclusion complex has been proved by fluorimetry, infrared, differential scanning calorimetry and one-dimensional (1D), 2D NMR. The experimental results confirmed the existence of 1:1 inclusion complex of ciprofloxacin with HP-β-CD. The formation constant of complex was determined by fluorescence method and 1 H NMR. Spacial configuration of complex has been proposed on two-dimensional NMR technique.
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