Abstract
The interaction of sparfloxacin with β-cyclodextrin (β-CD) has been studied by several analytical techniques, including 1H-NMR, 13C-NMR, fluorescence spectroscopy, infrared spectroscopy, thermal analysis, and scanning electron microscope. In this paper, solid inclusion complex of sparfloxacin with β-CD was synthesized by the coprecipitation method. In addition, the characterization of the inclusion complex has been proved by fluorimetry, Infrared, differential scanning calorimetry and 1D, 2D NMR. The experimental results confirmed the existence of 1:1 inclusion complex of sparfloxacin with β-CD. The formation constant of complex was determined by fluorescence method and 1H-NMR. Spacial configuration of complex has been proposed on 2D NMR techniques.
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