Abstract
90Y-FHMA (Ferric hydroxide macroaggregates) and 90Y-HA (hydroxyapatite) were prepared in >95% yield using 90Y from an in-house 90Sr–90Y generator. Most of the particles ranged from 5 to 20μm in diameter and retained radiochemical purity >95% in human serum for at least 7 days at 37°C. Gamma camera imaging of normal rabbits after intraarticulation of the particles showed complete retention of activity within the knee cavity with no measurable radioactivity leaching out of the joints over a 96 hour period.
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