Abstract
One therapeutic approach to rheumatoid arthritis and other inflammatory arthropathies besides surgical or chemical removal of inflamed synovium is radiation synovectomy using beta-emitting radionuclides to destroy the affected synovial tissue. In this study we compared 188Re labeled hydroxyapatite particles and 188Re rhenium sulfur colloid for their potential use in radiation synovectomy. After optimizing labeling conditions we achieved a labeling yield of more than 80 % for 188Re hydroxyapatite and more than 90 % for the rhenium sulfur colloid. In vitro stability studies showed that 188Re labeled hydroxyapatite particles lost about 80 % of their activity within 5 d in synovial fluid Rhenium sulfur colloid on the other hand proved to be very stable with a remaining activity of more than 93 % after 5 d in diluted synovial fluid.
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